What are the benefits of hyaluronic acid on the skin?

Hyaluronic acid has become one of the key ingredients in the field of dermatology and aesthetic medicine. Known for its moisturizing and anti-aging properties, this natural acid plays a key role in plumping the skin and filling in wrinkles . This article explores in detail the multiple benefits of hyaluronic acid on the skin, highlighting its role in maintaining hydration, restoring facial volume, and its use in aesthetic injections.

Understanding hyaluronic acid

Hyaluronic acid is a polymer naturally present in the human body, mainly in the skin, joints and eyes. It is an integral part of the extracellular matrix, where it acts as a binding and lubricating agent. However, with time and the aging process, the amount of hyaluronic acid in the skin decreases, leading to a loss of hydration, volume and the appearance of wrinkles.

Moisturizing properties of hyaluronic acid

One of the most notable characteristics of hyaluronic acid is its ability to retain water. In fact, a molecule of hyaluronic acid can retain up to 1000 times its weight in water . In other words, one gram of HA can hold up to six liters of water, which is an astonishing feat. This unique property helps keep the skin well hydrated, thus improving its suppleness, firmness and elasticity. By using skin care products containing hyaluronic acid, it is possible to revitalize the skin's surface and combat dehydration.

But there's more to know about hyaluronic acid. It's also a humectant, meaning it draws moisture to the skin, so think of it as a sponge or moisture magnet. HA helps skin cells retain water and regulate hydration levels. This means that when you apply a skincare product with HA, it can help maintain continuous hydration in the skin, all day long. Applying products with HA helps skin temporarily look plump and feel smooth.

Hyaluronic acid is a sugar molecule found naturally in the skin and it helps bind water to collagen, trapping it in the skin, so the skin can appear plumper, brighter and more hydrated. Basically, hyaluronic acid increases skin hydration, which can maintain a fresh, full, and plump appearance.

But that's not all hyaluronic acid can do. Hyaluronic acid can help with inflammation and wound healing. It also has antibacterial properties and is an antioxidant, meaning it can help protect against free radical damage.

Restoration of facial volume

Skin aging is often accompanied by a loss of volume in certain areas of the face, notably the cheeks, temples and contours. Hyaluronic acid, when used in aesthetic medicine, helps restore volume to these areas. Hyaluronic acid injections are commonly used to plump the skin , restore facial contours, and reduce the appearance of fine lines and wrinkles .

hyaluronic acid injection

Different types of hyaluronic acid

Hyaluronic acid used in cosmetic products can come from different sources, and it can be obtained by various methods, either by extraction or by synthesis. Here are some of the most common sources:

  • Extraction from animal sources: Historically, hyaluronic acid was extracted primarily from rooster combs and bull eyes. However, due to ethical concerns and the possibility of disease transmission, this method is becoming less common.
  • Extraction from microbial sources: Bacteria of the genus Streptococcus or Bacillus can be genetically modified to produce hyaluronic acid. This is a more common and ethically preferred method. These microorganisms are grown in large quantities under controlled laboratory conditions.
  • Extraction from plant sources: Some cosmetic products use hyaluronic acid extracted from plant sources such as mushrooms or wheat grains. This is an option that suits people who are concerned about ethical issues and prefer non-animal alternatives.
  • Laboratory synthesis: Today, most hyaluronic acid used in cosmetic products is produced by laboratory synthesis. This usually involves the fermentation of genetically modified bacteria to produce hyaluronic acid.

It is important to note that, regardless of the source, hyaluronic acid used in cosmetic products undergoes purification processes to ensure its safety and effectiveness. Manufacturers can adjust the molecular size of hyaluronic acid based on specific product needs, for example, using high or low molecular weight forms. These different molecular sizes may have specific properties for the skin, such as the ability to penetrate deeper or hydrate the skin's surface.

hyaluronic acid size

There are two main types of hyaluronic acid used in skin care products and cosmetic procedures: high molecular weight and low molecular weight hyaluronic acid.

  • High Molecular Weight Hyaluronic Acid : This form of hyaluronic acid is often used for its surface hydrating properties. It creates a protective barrier on the skin, preventing moisture loss and thus improving skin texture.

  • Low molecular weight hyaluronic acid : This type of hyaluronic acid penetrates deeper into the skin, acting at the extracellular matrix . It stimulates the skin's natural production of hyaluronic acid and promotes deep hydration.

Use of hyaluronic acid in aesthetic medicine

Hyaluronic acid injections have become a popular solution for treating signs of aging, such as wrinkles and loss of volume. Aesthetic doctors use hyaluronic acid injections to fill wrinkles, redefine facial contours and restore harmony to features. These procedures provide natural, temporary results, without requiring significant recovery time.

Hyaluronic acid as an anti-wrinkle and anti-aging agent

    In addition to its moisturizing properties, hyaluronic acid is also known for its anti-wrinkle effect. By filling the spaces between skin cells, it reduces the appearance of fine lines and wrinkles. This action makes skin look smoother and younger, providing a non-invasive way to combat the signs of aging.

    Precautions and advice for use

    Although hyaluronic acid products and injections are generally safe, it is essential to take certain precautions. People allergic to hyaluronic acid or other components of the product should avoid its use. Additionally, it is recommended to consult a healthcare professional or dermatologist before undertaking cosmetic procedures, to determine the best approach based on individual needs.


    In conclusion, hyaluronic acid is emerging as an essential ingredient in the field of skin care and aesthetic medicine. Its benefits for the skin, such as its hydrating power, its ability to restore facial volume and its anti-wrinkle action, make it a popular choice for those seeking a more youthful appearance and healthier skin. Whether through topical products or cosmetic injections, hyaluronic acid offers a versatile solution to meet the skin's diverse needs. However, it is always recommended to consult qualified healthcare professionals for advice tailored to each individual situation.


    1. Laura Laluque. Hyaluronic acid, a primitive molecule: interests and uses in community pharmacy. Life Sciences [q-bio]. 2020. ffdumas-03095496f
    2. The Derm Review. Everything You Need to Know about Hyaluronic Acid. 2020
    3. Bukhari SNA, Roswandi NL, Waqas M, Habib H, Hussain F, Khan S, Sohail M, Ramli NA, Thu HE, Hussain Z. Hyaluronic acid, a promising skin rejuvenating biomedicine: A review of recent updates and pre-clinical and clinical investigations on cosmetic and nutricosmetic effects. Int J Biol Macromol. 2018 Dec;120(Pt B):1682-1695. doi: 10.1016/j.ijbiomac.2018.09.188. Epub 2018 Oct 1. PMID: 30287361.
    4. Pereira H, Sousa DA, Cunha A, Andrade R, Espregueira-Mendes J, Oliveira JM, Reis RL. Hyaluronic Acid. Adv Exp Med Biol. 2018;1059:137-153. doi:10.1007/978-3-319-76735-2_6. PMID: 29736572.
    5. Juncan AM, Moisă DG, Santini A, Morgovan C, Rus LL, Vonica-Țincu AL, Loghin F. Advantages of Hyaluronic Acid and Its Combination with Other Bioactive Ingredients in Cosmeceuticals. Molecules. 2021 Jul 22;26(15):4429. doi:10.3390/molecules26154429. PMID: 34361586; PMCID: PMC8347214.